TY - JOUR T1 - Sex-specific Changes in Brain Estrogen Metabolism Induced by Acute Trimethyltin Exposure JF - In Vivo JO - In Vivo SP - 793 LP - 797 DO - 10.21873/invivo.12319 VL - 35 IS - 2 AU - JUNG HO LEE AU - SUNG-HEE CHO AU - EUN HYE JANG AU - SOON AE KIM Y1 - 2021/03/01 UR - http://iv.iiarjournals.org/content/35/2/793.abstract N2 - Background/Aim: In this study, we investigated sex-specific effects of acute exposure to trimethyltin, a known neurotoxicant on metabolic steroids. Materials and Methods: We administered intraperitoneally 2.3 mg/kg trimethyltin to 4-week-old male mice and measured the levels of metabolic steroids 24 h after treatment. We also measured mRNA and protein levels of cytochrome P450 1B1 using real-time polymerase chain reaction and western blotting. Results: Cortisol levels in the cortex increased in both sexes following acute trimethyltin exposure. The estradiol levels decreased, and the 4-hydroxyestradiol levels increased only in females. We also observed increased cytochrome P450 1B1 mRNA and protein levels only in the female cortex. Conclusion: Acute trimethyltin exposure induces distinct sex-specific metabolic changes in the brain before significant sexual maturation. ER -