PT  - JOURNAL ARTICLE
AU  - JUNG HO LEE
AU  - SUNG-HEE CHO
AU  - EUN HYE JANG
AU  - SOON AE KIM
TI  - Sex-specific Changes in Brain Estrogen Metabolism Induced by Acute Trimethyltin Exposure
AID  - 10.21873/invivo.12319
DP  - 2021 Mar 01
TA  - In Vivo
PG  - 793--797
VI  - 35
IP  - 2
4099  - http://iv.iiarjournals.org/content/35/2/793.short
4100  - http://iv.iiarjournals.org/content/35/2/793.full
SO  - In Vivo2021 Mar 01; 35
AB  - Background/Aim: In this study, we investigated sex-specific effects of acute exposure to trimethyltin, a known neurotoxicant on metabolic steroids. Materials and Methods: We administered intraperitoneally 2.3 mg/kg trimethyltin to 4-week-old male mice and measured the levels of metabolic steroids 24 h after treatment. We also measured mRNA and protein levels of cytochrome P450 1B1 using real-time polymerase chain reaction and western blotting. Results: Cortisol levels in the cortex increased in both sexes following acute trimethyltin exposure. The estradiol levels decreased, and the 4-hydroxyestradiol levels increased only in females. We also observed increased cytochrome P450 1B1 mRNA and protein levels only in the female cortex. Conclusion: Acute trimethyltin exposure induces distinct sex-specific metabolic changes in the brain before significant sexual maturation.