RT Journal Article SR Electronic T1 Sorafenib and Lenvatinib Treatment for Metastasis/Recurrence of Radioactive Iodine-refractory Differentiated Thyroid Carcinoma JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 1057 OP 1064 DO 10.21873/invivo.12350 VO 35 IS 2 A1 YASUHIRO ITO A1 NAOYOSHI ONODA A1 TAKUMI KUDO A1 HIROO MASUOKA A1 TAKUYA HIGASHIYAMA A1 MINORU KIHARA A1 AKIHIRO MIYA A1 AKIRA MIYAUCHI YR 2021 UL http://iv.iiarjournals.org/content/35/2/1057.abstract AB Background/Aim: Radioactive iodine-refractory differentiated thyroid carcinoma (RR-DTC) has been treated with multi-kinase inhibitors (MKIs), e.g., sorafenib (SOR) and lenvatinib (LEN). We analyzed the outcomes of RR-DTC patients who underwent SOR or LEN treatment at Kuma Hospital. Patients and Methods: We enrolled 21 and 18 patients treated with SOR and LEN, respectively. Results: The incidence of partial response in the LEN group was significantly higher than that in the SOR group. Serum thyroglobulin significantly decreased from the beginning of treatment to 1 month later in the LEN group (not in the SOR group). The neutrophil-lymphocyte ratio (NLR) was significantly decreased at 1 month later in both groups. An NLR ≥3 at the start of MKI treatment had a prognostic impact. Conclusion: For RR-DTC, LEN could be more effective than SOR, at least in the short term. The first-line drug should be selected based on other factors (e.g., adverse events, patient background).