TY - JOUR T1 - Risk Factors for Postoperative Liver Enzyme Elevation After Laparoscopic Gastrectomy for Gastric Cancer JF - In Vivo JO - In Vivo SP - 1227 LP - 1234 DO - 10.21873/invivo.12373 VL - 35 IS - 2 AU - AKIHIKO SANO AU - KANA SAITO AU - KENGO KURIYAMA AU - NOBUHIRO NAKAZAWA AU - YASUNARI UBUKATA AU - KEIGO HARA AU - MAKOTO SAKAI AU - KYOICHI OGATA AU - TAKAHARU FUKASAWA AU - MAKOTO SOHDA AU - MINORU FUKUCHI AU - HIROSHI NAITOH AU - KEN SHIRABE AU - HIROSHI SAEKI Y1 - 2021/03/01 UR - http://iv.iiarjournals.org/content/35/2/1227.abstract N2 - Background/Aim: Laparoscopic gastrectomy (LG) is more frequently associated with postoperative liver enzyme elevation (PLEE) than open gastrectomy in phase III clinical trials for Japanese gastric cancer patients. The aim of this study was to determine the risk factors for PLEE after LG for gastric cancer. Patients and Methods: This study enrolled 153 consecutive patients with gastric cancer who underwent LG. The patient characteristics, the liver retraction method [silicone disc (SD) or Nathanson liver retractor (NLR)], and perioperative outcomes were compared between patients with and without PLEE. Results: PLEE was observed in 26 patients (17%). The patients with PLEE exhibited longer operative times (p=0.005) and more frequent use of the NLR for liver retraction (p=0.022). In the multivariate analysis, liver retraction using the NLR (p=0.003) and aberrant left hepatic artery (ALHA) ligation (p=0.042) were independent risk factors of PLEE. Conclusion: Liver retraction with the SD during LG was shown to be the safer method that is less likely to cause postoperative liver dysfunction. ALHA preservation may contribute to avoiding postoperative liver dysfunction. ER -