TY - JOUR T1 - Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study JF - In Vivo JO - In Vivo SP - 731 LP - 741 DO - 10.21873/invivo.12314 VL - 35 IS - 2 AU - JACHYM ROSENDORF AU - MARKETA KLICOVA AU - LENKA CERVENKOVA AU - RICHARD PALEK AU - JANA HORAKOVA AU - ANDREA KLAPSTOVA AU - PETR HOSEK AU - VLADIMIRA MOULISOVA AU - LUKAS BEDNAR AU - VACLAV TEGL AU - ONDREJ BRZON AU - ZBYNEK TONAR AU - VLADISLAV TRESKA AU - DAVID LUKAS AU - VACLAV LISKA Y1 - 2021/03/01 UR - http://iv.iiarjournals.org/content/35/2/731.abstract N2 - Background/Aim: Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation. Materials and Methods: Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation. Results: The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups. Conclusion: Nanofibrous materials may prevent anastomotic leakage but delay healing. ER -