PT  - JOURNAL ARTICLE
AU  - ROSENDORF, JACHYM
AU  - KLICOVA, MARKETA
AU  - CERVENKOVA, LENKA
AU  - PALEK, RICHARD
AU  - HORAKOVA, JANA
AU  - KLAPSTOVA, ANDREA
AU  - HOSEK, PETR
AU  - MOULISOVA, VLADIMIRA
AU  - BEDNAR, LUKAS
AU  - TEGL, VACLAV
AU  - BRZON, ONDREJ
AU  - TONAR, ZBYNEK
AU  - TRESKA, VLADISLAV
AU  - LUKAS, DAVID
AU  - LISKA, VACLAV
TI  - Double-layered Nanofibrous Patch for Prevention of Anastomotic Leakage and Peritoneal Adhesions, Experimental Study
AID  - 10.21873/invivo.12314
DP  - 2021 Mar 01
TA  - In Vivo
PG  - 731--741
VI  - 35
IP  - 2
4099  - http://iv.iiarjournals.org/content/35/2/731.short
4100  - http://iv.iiarjournals.org/content/35/2/731.full
SO  - In Vivo2021 Mar 01; 35
AB  - Background/Aim: Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation. Materials and Methods: Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation. Results: The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups. Conclusion: Nanofibrous materials may prevent anastomotic leakage but delay healing.