TY - JOUR T1 - Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System JF - In Vivo JO - In Vivo SP - 993 LP - 998 DO - 10.21873/invivo.12342 VL - 35 IS - 2 AU - SHIRO FUJITA AU - KATSUHIRO MASAGO AU - EIICHI SASAKI AU - SATOSHI TSUKUSHI AU - YOSHITSUGU HORIO AU - HIROAKI KURODA AU - TOYOAKI HIDA Y1 - 2021/03/01 UR - http://iv.iiarjournals.org/content/35/2/993.abstract N2 - Background/Aim: The Archer FusionPlex platform is widely used for comprehensive fusion-gene detection in cancer tissues. This platform separately displays results for strong-evidence and weak-evidence fusion candidates (WEFCs). Distinctive fusion patterns are frequently found in the weak-evidence category and information about the patterns is clinically essential. Patients and Methods: We describe the type and frequency of WEFCs observed using the FusionPlex Sarcoma Panel (S Panel) and the FusionPlex ALK, RET, and ROS1 ver2 Panel (ARR Panel). Results: A total of 97 specimens were examined and 620 candidates were detected and categorized as WEFCs. A median of five WEFCs were detected per sample. In the S Panel group, there were 13 WEFCs with a frequency of more than 1%. In the ARR Panel group, a total of 16 WEFCs were detected with a frequency of more than 1%. Conclusion: Specific WEFCs were detected according to the panel selected. ER -