PT  - JOURNAL ARTICLE
AU  - FUJITA, SHIRO
AU  - MASAGO, KATSUHIRO
AU  - SASAKI, EIICHI
AU  - TSUKUSHI, SATOSHI
AU  - HORIO, YOSHITSUGU
AU  - KURODA, HIROAKI
AU  - HIDA, TOYOAKI
TI  - Weak-evidence Fusion Candidates Detected by a FusionPlex Assay Using the Ion Torrent System
AID  - 10.21873/invivo.12342
DP  - 2021 Mar 01
TA  - In Vivo
PG  - 993--998
VI  - 35
IP  - 2
4099  - http://iv.iiarjournals.org/content/35/2/993.short
4100  - http://iv.iiarjournals.org/content/35/2/993.full
SO  - In Vivo2021 Mar 01; 35
AB  - Background/Aim: The Archer FusionPlex platform is widely used for comprehensive fusion-gene detection in cancer tissues. This platform separately displays results for strong-evidence and weak-evidence fusion candidates (WEFCs). Distinctive fusion patterns are frequently found in the weak-evidence category and information about the patterns is clinically essential. Patients and Methods: We describe the type and frequency of WEFCs observed using the FusionPlex Sarcoma Panel (S Panel) and the FusionPlex ALK, RET, and ROS1 ver2 Panel (ARR Panel). Results: A total of 97 specimens were examined and 620 candidates were detected and categorized as WEFCs. A median of five WEFCs were detected per sample. In the S Panel group, there were 13 WEFCs with a frequency of more than 1%. In the ARR Panel group, a total of 16 WEFCs were detected with a frequency of more than 1%. Conclusion: Specific WEFCs were detected according to the panel selected.