TY - JOUR T1 - Incidental Gallbladder Cancer on Cholecystectomy: Strategy for Re-resection of Presumed Benign Diseases from a Retrospective Multicenter Study by the Yokohama Clinical Oncology Group JF - In Vivo JO - In Vivo SP - 1217 LP - 1225 DO - 10.21873/invivo.12372 VL - 35 IS - 2 AU - RYUSEI MATSUYAMA AU - KENICHI MATSUO AU - RYUTARO MORI AU - MITSUTAKA SUGITA AU - NAOTAKA YAMAGUCHI AU - TORU KUBOTA AU - KUNIO KAMEDA AU - YASUHISA MOCHIZUKI AU - RYO TAKAGAWA AU - TOSHIAKI KADOKURA AU - GORO MATSUDA AU - NORIYUKI KAMIYA AU - ITARU ENDO Y1 - 2021/03/01 UR - http://iv.iiarjournals.org/content/35/2/1217.abstract N2 - Background/Aim: Current expert consensus recommends re-resection for incidental gallbladder cancer (IGBC) of pT1b-3. This study examined whether this consensus was reasonably applicable to patients with IGBC in one Japanese region. Patients and Methods: This was a multicenter, retrospective analysis of cholecystectomies for presumed benign diseases between January 2000 and December 2009. Results: IGBC was diagnosed in 70 (1.0%) out of 6,775 patients undergoing cholecystectomy. Five-year disease-specific cumulative survival was 100% in 19 patients with pT1a, 80.0% in five with pT1b, 49.5% in 33 with pT2, and 23.1% in 13 with pT3. Re-resection was not performed for the 24 patients with pT1a/1b disease, whereas 24 out of 46 patients with pT2/3 underwent re-resection. Regardless of re-resection, independent factors associated with a poor prognosis on multivariate analysis were grade 2 or poorer disease and bile spillage at prior cholecystectomy. In the 24 patients with pT2/3 re-resection, 11 patients without either of these two factors had significantly better 5-year disease-specific cumulative survival than the 13 patients with one or two independent factors associated with a poor prognosis (72.7% vs. 30.8%, p=0.009). Conclusion: This Japanese regional study suggests that indication of re-resection for IGBC should not be determined by pT-factor alone and that much more attention should be paid to pathological and intraoperative findings at prior cholecystectomy. ER -