PT - JOURNAL ARTICLE AU - YUKI MUKAI AU - NAHO RUIZ YOKOTA AU - MADOKA SUGIURA AU - TAICHI MIZUSHIMA AU - RISA TANIUCHI AU - YUICHI IMAI AU - KOTARO HASHIMOTO AU - YUYA TABUCHI AU - ETUSKO MIYAGI AU - MASAHARU HATA TI - Outcome of Radiation Therapy for Stage IVB Uterine Cervical Cancer With Distant Lymph Nodes Metastases; Sequential Irradiation for Distant Lymph Nodes Metastases AID - 10.21873/invivo.12365 DP - 2021 Mar 01 TA - In Vivo PG - 1169--1176 VI - 35 IP - 2 4099 - http://iv.iiarjournals.org/content/35/2/1169.short 4100 - http://iv.iiarjournals.org/content/35/2/1169.full SO - In Vivo2021 Mar 01; 35 AB - Background/Aim: This study aimed to evaluate the outcome of radiation therapy for patients with distant lymph node (LN) metastases, without organ metastases from uterine cervical cancer (UCC). Patients and Methods: Twenty-six patients with UCC with distant LN metastases received radiotherapy and were retrospectively analyzed. The sites of distant LN metastasis were as follows; Supraclavicular in 19, inguinal in nine, axillary in four, and others in three. The mean dose prescribed for these was 50 (range=40-60) Gy. Results: The 2-year overall, cause-specific, and progression-free survival, and local control of primary tumor rates were 51.3%, 51.3%, 46.9%, and 67.9%. In multivariate analysis, performance status ≥1 (p=0.007), para-aortic LN metastases (p=0.001), and lack of high-dose-rate intracavitary brachytherapy (p=0.033) were significantly associated with poor overall survival. Performance status ≥1 (p=0.004), and para-aortic LN metastases (p=0.014) were significantly associated with poor cause-specific survival. Conclusion: This study demonstrated favorable local control in patients with UCC with distant LN metastases.