@article {CHUNG1109, author = {YOUN KYUNG CHUNG and YOUNG-KYUN LEE and BYUNG-HO YOON and DONG HOON SUH and KYUNG-HOI KOO}, title = {Pelvic Insufficiency Fractures in Cervical Cancer After Radiation Therapy: A Meta-Analysis and Review}, volume = {35}, number = {2}, pages = {1109--1115}, year = {2021}, doi = {10.21873/invivo.12356}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: The aim of the study was to estimate the prevalence of pelvic insufficiency fractures (PIFs) after radiation therapy (RT) in patients with cervical cancer. Patients and Methods: A total of 3,633 patients from 15 cohort studies were included. Proportion meta-analysis was performed to estimate prevalence and subgroup analysis was performed according to imaging modalities for diagnosis of PIF. For continuous variables (age and length of follow-up), meta-regression analysis was performed. Results: Pooled prevalence estimate of PIF was 14\% (95\% CI=10-19). Incidence of PIF was higher in studies that used MRI as a diagnostic tool (17\%, 95\% CI=12-22) than non-MRI (8\%, 95\% CI=2-14). In meta-regression, we found a significant association of prevalence of PIF with age (p=0.021) but not with length of follow-up (p=0.118). Conclusion: PIF after RT in patients with cervical cancer is not rare. Physicians need to pay attention to PIFs, especially in patients with high-risk factors for osteoporotic fracture.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/35/2/1109}, eprint = {https://iv.iiarjournals.org/content/35/2/1109.full.pdf}, journal = {In Vivo} }