PT - JOURNAL ARTICLE AU - NAGARAJAN MAHARAJAN AU - GWANG-WON CHO AU - JI HYUN CHOI AU - CHUL HO JANG TI - Regenerative Therapy Using Umbilical Cord Serum AID - 10.21873/invivo.12310 DP - 2021 Mar 01 TA - In Vivo PG - 699--705 VI - 35 IP - 2 4099 - http://iv.iiarjournals.org/content/35/2/699.short 4100 - http://iv.iiarjournals.org/content/35/2/699.full SO - In Vivo2021 Mar 01; 35 AB - Regenerative medicine is a branch of medicine that incorporates tissue-engineering, biomaterials, and cell therapy approaches to replace or repair damaged cells and tissues. Umbilical cord serum (UCS) is an important liquid component of cord blood, which has a reliable source of innumerable growth factors and biologically active molecules. Usually, serum can be prepared from different sources of blood. In therapeutic application, cord serum can be prepared and used in the form of eye drops for the treatment of severe dry eye diseases, ocular burns, glaucoma, persistent corneal epithelial defects and neurotrophic keratitis. In addition, cord serum combined with synthetic bio scaffold materials is used to regenerate different types of tissues including tympanic membrane regeneration, bone regeneration and nerve regeneration. Absence of animal origin viruses and bacteria, lack of xenoproteins and cost-effective features make cord serum a feasible choice as replacement of fetal bovine serum in cell culture techniques. Thus, this review emphasizes the role of cord serum in regenerative therapy and clinical uses.