RT Journal Article SR Electronic T1 Dosimetric Comparison Between Carbon-ion Radiotherapy and Photon Radiotherapy for Stage I Esophageal Cancer JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 447 OP 452 DO 10.21873/invivo.12277 VO 35 IS 1 A1 YOSUKE TAKAKUSAGI A1 DAISAKU YOSHIDA A1 YOHSUKE KUSANO A1 KIO KANO A1 WATARU ANNO A1 KEISUKE TSUCHIDA A1 NOBUTAKA MIZOGUCHI A1 ITSUKO SERIZAWA A1 HIROYUKI KATOH A1 KOH IMURA A1 YOSHIKI TAKAYAMA A1 SHINICHI MINOHARA A1 TADASHI KAMADA YR 2021 UL http://iv.iiarjournals.org/content/35/1/447.abstract AB Background/Aim: The present study aimed to compare the radiation dose distribution of carbon-ion radiotherapy (CIRT) for stage I esophageal cancer with three-dimensional conformal radiotherapy (3DCRT) and volumetric modulated arc therapy (VMAT). Patients and Methods: Fifteen patients with cT1bN0M0 esophageal cancer who received 3DCRT at Kanagawa Cancer Center between January 2014 and April 2019 were enrolled. The dose-volume histogram parameters of the target volume and normal organs planned with CIRT, 3DCRT, and VMAT were evaluated. Results: The homogeneity index for the target volume of CIRT was significantly lower than that of 3DCRT and VMAT. In addition, the radiation dose of CIRT to the heart, lungs, spinal cord, and skin was significantly lower than that of 3DCRT and VMAT. Conclusion: Favorable dose distributions with CIRT were demonstrated compared with 3DCRT and VMAT for esophageal cancer.