TY - JOUR T1 - High MCM6 Expression as a Potential Prognostic Marker in Clear-cell Renal Cell Carcinoma JF - In Vivo JO - In Vivo SP - 299 LP - 306 DO - 10.21873/invivo.12259 VL - 35 IS - 1 AU - NU-RI JANG AU - JINA BAEK AU - YOUNGHWII KO AU - PHIL HYUN SONG AU - MI-JIN GU Y1 - 2021/01/01 UR - http://iv.iiarjournals.org/content/35/1/299.abstract N2 - Aim: Minichromosome maintenance (MCM) proteins are involved in initiation of DNA replication and cell-cycle progression. Loss of MCM function results in genomic instability and causes carcinogenesis. Among MCM genes, the role and prognostic value of MCM6 expression in clear-cell renal cell carcinoma (ccRCC) has not been elucidated. Materials and Methods: We assessed the mRNA expression level of MCM6 using the Gene Expression Profiling Interactive Analysis database and investigated MCM6 protein expression by immunohistochemistry in 238 ccRCC cases. Results: High MCM6 expression was significantly associated with increasing tumor size, pT, stage, tumor necrosis, and metastasis. Furthermore, high MCM6 expression was significantly associated with shorter overall and disease-free survival, and was an independent unfavorable prognostic marker. Regarding patients with metastasis, high MCM6-expressing ccRCC conferred significantly shorter survival than for those with low expression. Conclusion: A high MCM6 expression level may be a promising biomarker to predict tumor progression, metastasis, and survival in patients with ccRCC. ER -