%0 Journal Article %A CĂTĂLIN GABRIEL HERGHELEGIU %A ADRIAN NEACȘU %A RALUCA CHIRCURESCU %A DORU HERGHELEGIU %A SILVIU CRISTIAN VOINEA %A CAMELIA DIACONU %A OVIDIU STIRU %A CORNEL SAVU %A ALEXANDRU FILIPESCU %A IRINA BALESCU %A NICOLAE BACALBASA %A NICOLAE SUCIU %T Pathological Examination of the Late Embryonic Heart Using the Same 4-chamber and 3-vessel Planes Used in Fetal Echocardiography %D 2021 %R 10.21873/invivo.12288 %J In Vivo %P 533-539 %V 35 %N 1 %X Background/Aim: The incidence of early pregnancy loss widely varies according to age, being considerably higher in older women. Severe congenital malformations play an important role in pregnancy loss, having a high risk of recurrence. Congenital heart defects are the most common congenital abnormalities, thus the diagnosis of such malformations in aborted embryos is important for establishing both a possible cause for pregnancy loss and for correctly counseling the parents. Pathologic examination of the heart that is only a few millimeters in size, is very challenging. Patients and Methods: A pathologic examination protocol using transverse microscopic sections at the level of the 4-chamber and 3-vessel planes is proposed for heart evaluation. Results: Two 9-10 gestational weeks embryos were microscopically examined using transverse slides of the thorax. The 4-chamber and 3-vessel slides were analyzed and compared to 11-13 weeks ultrasound images of the 4-chamber and 3-vessel views from 10 cases. The pathologic examination provided a detailed view of the ventricles, atria and great vessels, sometime surpassing even the ultrasound examination that was performed at a later gestational age. Conclusion: We consider our proposed pathologic examination protocol feasible for evaluating normal heart structures and ruling out severe congenital heart disease. %U https://iv.iiarjournals.org/content/invivo/35/1/533.full.pdf