TY - JOUR T1 - IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular Leucomalacia Model JF - In Vivo JO - In Vivo SP - 307 LP - 312 DO - 10.21873/invivo.12260 VL - 35 IS - 1 AU - DONG-JOON KIM AU - SU-YEON CHO AU - SEUNG-UN KIM AU - DONG-WON JO AU - HYO-IN HWANG AU - HYE-KYOUNG SHIN AU - YONG-HYUN JUN Y1 - 2021/01/01 UR - http://iv.iiarjournals.org/content/35/1/307.abstract N2 - Background/Aim: Chronic cerebral hypoperfusion affects early and mature neurons in the subventricular zone (SVZ) and cerebral cortex. Herein, we investigated the effects of insulin-like growth factor-1 (IGF-1), a neurogenesis-promoting agent, on neurons in these regions in periventricular leucomalacia (PVL) model rats. Materials and Methods: Following right carotid artery ligation, the rats were placed in a hypoxia chamber and injected with recombinant IGF-1 (0.1 and 1 μg/μl). Their brain sections were immunohistochemically analysed using anti-nestin and anti-NeuN antibodies. Results: The numbers of early-neuronal cells in the SVZ and mature neurons in the cerebral cortex were higher and lower, respectively, in the PVL group than in the control group. The number of NeuN-positive cells was significantly higher in the IGF-treated group than in the PVL group. Conclusion: PVL increased the number of early neuronal cells in the SVZ, reducing the survival of mature neurons in the cerebral cortex; IGF-1 reversed these effects. ER -