PT  - JOURNAL ARTICLE
AU  - DONG-JOON KIM
AU  - SU-YEON CHO
AU  - SEUNG-UN KIM
AU  - DONG-WON JO
AU  - HYO-IN HWANG
AU  - HYE-KYOUNG SHIN
AU  - YONG-HYUN JUN
TI  - IGF-1 Protects Neurons in the Cortex and Subventricular Zone in a Periventricular Leucomalacia Model
AID  - 10.21873/invivo.12260
DP  - 2021 Jan 01
TA  - In Vivo
PG  - 307--312
VI  - 35
IP  - 1
4099  - http://iv.iiarjournals.org/content/35/1/307.short
4100  - http://iv.iiarjournals.org/content/35/1/307.full
SO  - In Vivo2021 Jan 01; 35
AB  - Background/Aim: Chronic cerebral hypoperfusion affects early and mature neurons in the subventricular zone (SVZ) and cerebral cortex. Herein, we investigated the effects of insulin-like growth factor-1 (IGF-1), a neurogenesis-promoting agent, on neurons in these regions in periventricular leucomalacia (PVL) model rats. Materials and Methods: Following right carotid artery ligation, the rats were placed in a hypoxia chamber and injected with recombinant IGF-1 (0.1 and 1 μg/μl). Their brain sections were immunohistochemically analysed using anti-nestin and anti-NeuN antibodies. Results: The numbers of early-neuronal cells in the SVZ and mature neurons in the cerebral cortex were higher and lower, respectively, in the PVL group than in the control group. The number of NeuN-positive cells was significantly higher in the IGF-treated group than in the PVL group. Conclusion: PVL increased the number of early neuronal cells in the SVZ, reducing the survival of mature neurons in the cerebral cortex; IGF-1 reversed these effects.