TY - JOUR T1 - Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer JF - In Vivo JO - In Vivo SP - 131 LP - 140 DO - 10.21873/invivo.12240 VL - 35 IS - 1 AU - SEONGSIK BANG AU - SEUNGYUN JEE AU - HYUNSUNG KIM AU - KISEOK JANG AU - HOSUB PARK AU - JAE KYUNG MYUNG AU - DONGHO CHOI AU - SU-JIN SHIN AU - SEUNG SAM PAIK Y1 - 2021/01/01 UR - http://iv.iiarjournals.org/content/35/1/131.abstract N2 - Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis. ER -