PT  - JOURNAL ARTICLE
AU  - SEONGSIK BANG
AU  - SEUNGYUN JEE
AU  - HYUNSUNG KIM
AU  - KISEOK JANG
AU  - HOSUB PARK
AU  - JAE KYUNG MYUNG
AU  - DONGHO CHOI
AU  - SU-JIN SHIN
AU  - SEUNG SAM PAIK
TI  - Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer
AID  - 10.21873/invivo.12240
DP  - 2021 Jan 01
TA  - In Vivo
PG  - 131--140
VI  - 35
IP  - 1
4099  - http://iv.iiarjournals.org/content/35/1/131.short
4100  - http://iv.iiarjournals.org/content/35/1/131.full
SO  - In Vivo2021 Jan 01; 35
AB  - Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis.