%0 Journal Article %A SEONGSIK BANG %A SEUNGYUN JEE %A HYUNSUNG KIM %A KISEOK JANG %A HOSUB PARK %A JAE KYUNG MYUNG %A DONGHO CHOI %A SU-JIN SHIN %A SEUNG SAM PAIK %T Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer %D 2021 %R 10.21873/invivo.12240 %J In Vivo %P 131-140 %V 35 %N 1 %X Background/Aim: Dual-specificity protein phosphatase 4 (DUSP4) negatively regulates MAPK signaling and is involved in various cellular processes. We herein evaluated the relationship between DUSP4 expression and clinicopathological characteristics in a large series of gastric cancer samples. Materials and Methods: DUSP4 expression was examined by immunohistochemistry in 508 gastric cancer samples. Cases were classified according to the TCGA molecular classification and HER2 amplification. Kaplan-Meier plots were used to predict the relationship between mRNA expression of DUSP4 and survival. Results: Low expression of DUSP4 was significantly correlated with larger tumor size, higher pT category, positive nodal status, higher stage, lymphovascular invasion, perineural invasion, worse overall survival, and worse recurrence-free survival. No correlation was observed between DUSP4 expression and molecular characteristics. Bioinformatics analysis showed that low mRNA expression was associated with a poor prognosis. Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis. %U https://iv.iiarjournals.org/content/invivo/35/1/131.full.pdf