RT Journal Article
SR Electronic
T1 Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 81
OP 93
DO 10.21873/invivo.12235
VO 35
IS 1
A1 NIKOLAOS GARMPIS
A1 CHRISTOS DAMASKOS
A1 ANNA GARMPI
A1 VASILIKI E. GEORGAKOPOULOU
A1 STRATIGOULA SAKELLARIOU
A1 ALIKI LIAKEA
A1 DIMITRIOS SCHIZAS
A1 EVANGELOS DIAMANTIS
A1 PARASKEVI FARMAKI
A1 ERRIKA VOUTYRITSA
A1 ATHANASIOS SYLLAIOS
A1 ALEXANDROS PATSOURAS
A1 GEORGIA SYPSA
A1 ALEXANDRA AGOROGIANNI
A1 ATHANASIA STELIANIDI
A1 EFSTATHIOS A. ANTONIOU
A1 KONSTANTINOS KONTZOGLOU
A1 NIKOLAOS TRAKAS
A1 DIMITRIOS DIMITROULIS
YR 2021
UL http://iv.iiarjournals.org/content/35/1/81.abstract
AB Background/Aim: Inflammatory fibroid polyp (IFP) is a rare, usually solitary and intraluminal polypoid benign tumor that can affect any part of the gastrointestinal (GI) tract, although in the majority of cases it affects the stomach. This lesion is characterized by proliferation of highly vascular fibrous tissue and infiltration by a variable number of different inflammatory cells. Its etiology is unknown. Our aim was to describe all the reported data concerning IFP. Materials and Methods: An extensive search of the PubMed Index was performed for publications with titles or abstracts containing the terms: “inflammatory fibroid polyp” with/without “Vanek”. Results were filtered for publications in English and concerning only humans. One hundred and twenty-four publications were finally included in this review. Results: IFP has a female predominance. It affects patients in their 5th decade of life, although there are cases of patients from 4 to 84 years of age. IFP usually affects the stomach and more specifically the gastric antrum but can be detected throughout the GI tract. A significant number of cases remain asymptomatic but the most frequent presentations of IFP are abdominal pain, acute abdomen and GI bleeding. Most cases are treated by endoscopic resection of the lesion. No recurrence nor IFP-specific complications have been reported. Histopathology of IFP varies. Conclusion: It is relatively safe to conclude that both the etiology and the timing of diagnosis might change the histopathology, immunohistological staining and tissue structure of IFP. Suggested theories should be taken into consideration with caution as the etiology and pathophysiological mechanisms of IFP are unknown.