@article {ATMODJO291, author = {WAHYUNI LUKITA ATMODJO and YOUNG OTHIWI LARASATI and JUANDY JO and RISKA NUFIKA and STEFFI NAOMI and IMELDA WINOTO}, title = {Relationship Between Insulin-Receptor Substrate 1 and Langerhans{\textquoteright} Islet in a Rat Model of Type 2 Diabetes Mellitus}, volume = {35}, number = {1}, pages = {291--297}, year = {2021}, doi = {10.21873/invivo.12258}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: In vivo studies on pathogenesis of type 2 diabetes mellitus (T2DM) have been reported, however, the relationship between insulin-receptor substrate 1 (IRS1) and the area of Langerhans{\textquoteright} islets was unknown. Therefore, a correlation between both parameters was assessed. Materials and Methods: Diabetic groups were fed with a high-fat diet (HFD) and injected with three different doses of streptozotocin, namely 25, 35 and 45 mg/kg, and compared to a control group after 9 weeks. Results: Administration of HFD/streptozotocin increased the level of fasting blood glucose but reduced the level of IRS1 and the area of Langerhans{\textquoteright} islets in diabetic groups. The coefficient of correlation between IRS1 and area of Langerhans{\textquoteright} islets was 0.259 (p=0.232). In addition, the coefficient of correlation for fasting blood glucose with the area of Langerhans{\textquoteright} islets and IRS1 was -0.520 (p=0.011) and -0.603 (p=0.002), respectively. Conclusion: The reduction of IRS1 was weakly correlated with the destruction of Langerhans{\textquoteright} islets, suggesting there is an intermediate step between both parameters.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/35/1/291}, eprint = {https://iv.iiarjournals.org/content/35/1/291.full.pdf}, journal = {In Vivo} }