PT - JOURNAL ARTICLE AU - HIROAKI MIYAKE AU - KOJI MURONO AU - KAZUSHIGE KAWAI AU - HIROAKI NOZAWA AU - HARUFUMI MAKI AU - KIYOSHI HASEGAWA AU - JUN NAKAJIMA AU - SOICHIRO ISHIHARA TI - Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time AID - 10.21873/invivo.12175 DP - 2020 Nov 01 TA - In Vivo PG - 3367--3374 VI - 34 IP - 6 4099 - http://iv.iiarjournals.org/content/34/6/3367.short 4100 - http://iv.iiarjournals.org/content/34/6/3367.full SO - In Vivo2020 Nov 01; 34 AB - Background/Aim: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC). Patients and Methods: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography. Results: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases. Conclusion: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT.