TY - JOUR T1 - Impact of Surgical Resection on Metachronous Metastases of Colorectal Cancer According to Tumor Doubling Time JF - In Vivo JO - In Vivo SP - 3367 LP - 3374 DO - 10.21873/invivo.12175 VL - 34 IS - 6 AU - HIROAKI MIYAKE AU - KOJI MURONO AU - KAZUSHIGE KAWAI AU - HIROAKI NOZAWA AU - HARUFUMI MAKI AU - KIYOSHI HASEGAWA AU - JUN NAKAJIMA AU - SOICHIRO ISHIHARA Y1 - 2020/11/01 UR - http://iv.iiarjournals.org/content/34/6/3367.abstract N2 - Background/Aim: We aimed to elucidate the prognostic impact of tumor doubling time (DT) and radical surgery when classified by DT in patients with metachronous liver, lung, or peritoneal metastases of colorectal cancer (CRC). Patients and Methods: We reviewed the data of 1941 patients who underwent curative surgery for CRC and calculated DT for recurrences using computed tomography. Results: Short DT was an independent prognostic risk factor in liver (p<0.001) and peritoneal (p=0.03) metastases. Survival was significantly better in patients who underwent surgery than in those who did not, both in short and long DT groups in any metastatic organ (p<0.01). Patients with long DT gained significantly better prognostic benefit from surgery than those with short DT in liver (p=0.01) and peritoneal (p=0.04) metastases. Conclusion: Surgery is recommended for resectable metastases, especially in patients with liver and peritoneal metastases with long DT. ER -