TY - JOUR T1 - Changing Patterns of Distant Metastasis in Patients With Lower Rectal Cancer Undergoing Intraoperative Radiotherapy JF - In Vivo JO - In Vivo SP - 3655 LP - 3659 DO - 10.21873/invivo.12212 VL - 34 IS - 6 AU - TADAHIKO MASAKI AU - HIROYOSHI MATSUOKA AU - TOMOKAZU KISHIKI AU - KOICHIRO KOJIMA AU - AYAKO TONARI AU - NOBUYOSHI ASO AU - AYUMI BENIYA AU - AIKO IIOKA AU - TAKASHI WAKAMATSU AU - EIJI SUNAMI Y1 - 2020/11/01 UR - http://iv.iiarjournals.org/content/34/6/3655.abstract N2 - Background/Aim: Local radiotherapy for primary tumors may increase the incidence of distant metastasis. However, the patterns of target organs have not been clarified yet. Patients and Methods: In our randomized controlled trial examining the oncological efficacy of intraoperative radiotherapy (IORT) for advanced lower rectal cancer, the details of the metastatic organs were evaluated. Results: In the IORT group (38 patients), 2 patients had metastasis in the liver and lung simultaneously, 9 in the liver, and 4 in the lung. In the control group (38 patients), 3 had metastasis in the lung, and 2 in the liver. The IORT group tended to have liver metastases more frequently (p=0.058). Among patients with liver metastases, distant metastasis-free intervals were significantly shorter in the IORT group, however, no significant difference was observed among patients with lung metastases. Conclusion: After curative rectal cancer surgery with IORT, liver metastasis may be increased and accelerated. ER -