PT  - JOURNAL ARTICLE
AU  - MASAKI, TADAHIKO
AU  - MATSUOKA, HIROYOSHI
AU  - KISHIKI, TOMOKAZU
AU  - KOJIMA, KOICHIRO
AU  - TONARI, AYAKO
AU  - ASO, NOBUYOSHI
AU  - BENIYA, AYUMI
AU  - IIOKA, AIKO
AU  - WAKAMATSU, TAKASHI
AU  - SUNAMI, EIJI
TI  - Changing Patterns of Distant Metastasis in Patients With Lower Rectal Cancer Undergoing Intraoperative Radiotherapy
AID  - 10.21873/invivo.12212
DP  - 2020 Nov 01
TA  - In Vivo
PG  - 3655--3659
VI  - 34
IP  - 6
4099  - http://iv.iiarjournals.org/content/34/6/3655.short
4100  - http://iv.iiarjournals.org/content/34/6/3655.full
SO  - In Vivo2020 Nov 01; 34
AB  - Background/Aim: Local radiotherapy for primary tumors may increase the incidence of distant metastasis. However, the patterns of target organs have not been clarified yet. Patients and Methods: In our randomized controlled trial examining the oncological efficacy of intraoperative radiotherapy (IORT) for advanced lower rectal cancer, the details of the metastatic organs were evaluated. Results: In the IORT group (38 patients), 2 patients had metastasis in the liver and lung simultaneously, 9 in the liver, and 4 in the lung. In the control group (38 patients), 3 had metastasis in the lung, and 2 in the liver. The IORT group tended to have liver metastases more frequently (p=0.058). Among patients with liver metastases, distant metastasis-free intervals were significantly shorter in the IORT group, however, no significant difference was observed among patients with lung metastases. Conclusion: After curative rectal cancer surgery with IORT, liver metastasis may be increased and accelerated.