RT Journal Article
SR Electronic
T1 Solitary Fibrous Tumor of the Orbit: A Clinicopathologic Study of Two Cases With Review of the Literature
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3649
OP 3654
DO 10.21873/invivo.12211
VO 34
IS 6
A1 MIZUHO MITAMURA
A1 SATORU KASE
A1 YASUO SUZUKI
A1 TAKATOSHI SAKAGUCHI
A1 YUKA SUIMON
A1 YOKO DONG
A1 KANAKO C. HATANAKA
A1 TOSHIYA SINOHARA
A1 MANABU KASE
A1 SUSUMU ISHIDA
YR 2020
UL http://iv.iiarjournals.org/content/34/6/3649.abstract
AB Background/Aim: Orbital solitary fibrous tumor (SFT) is a rare lesion among orbital tumors, which can be misdiagnosed as another mesenchymal tumor. In this study we report two cases of orbital SFT, focusing on the imaging and pathological findings of the vascular structure inside the tumor. Case Report: A 26-year-old woman and 43-year-old man presented with orbital SFT. The pathological findings revealed a patternless growth pattern of the tumor cells and hemangiopericytoma-like vascularity as well as thickened, dilated blood vessels within the tumor tissue. Tumor cells revealed a diffuse strong positivity for cluster of differentiation 34 (CD34) and signal transducer and activator of transcription 6 (STAT6) in both cases, while B-cell lymphoma 2 (bcl-2) and CD99 were positive in one case. Characteristic findings within the tumor were the arterial components, where a variety of STAT6, CD99 and bcl-2-positive smooth muscle cells were intermingled. Conclusion: Histologically, the tumor tissues might be characterized by not only conventional hemangiopericytoma-like vasculature but also dilated arterial vessels, which were shown to be part of the tumor components.