TY - JOUR T1 - Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan JF - In Vivo JO - In Vivo SP - 3181 LP - 3186 DO - 10.21873/invivo.12153 VL - 34 IS - 6 AU - LI-HSIOU CHEN AU - KUO-LIANG CHIU AU - TE-CHUN HSIA AU - YEN-HSIEN LEE AU - TE-CHUN SHEN AU - CHIA-HSIANG LI AU - YI-CHENG SHEN AU - WEN-SHIN CHANG AU - CHIA-WEN TSAI AU - DA-TIAN BAU Y1 - 2020/11/01 UR - http://iv.iiarjournals.org/content/34/6/3181.abstract N2 - Background/Aim: Matrix metalloproteinase 2 (MMP2) is reported to be overexpressed in asthma; however, its genotypic contribution to asthma is not well studied. Therefore, we examined the association of MMP2 genotypes with asthma risk among Taiwanese. Materials and Methods: One hundred and ninety-eight asthma patients and 453 non-asthmatic subjects were determined with respect to their MMP2 -1306 (rs243845) and -735 (rs2285053) genotypes. Results: CT and TT at MMP2 rs243845 are 17.7% and 1.5% among asthma cases, whereas their presence in healthy subjects is at 28.1% and 2.4%, respectively (p for trend=0.0118). In detail, the CT genotype in MMP2 rs243845 was associated with a decreased asthma risk [adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.37-0.78, p=0.0040], and the T allele conferred a significantly lower asthma risk compared to the wild-type C allele (adjusted OR=0.55, 95%CI=0.43-0.77, p=0.0042). No significance was found for MMP2 rs2285053. Conclusion: The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan. ER -