RT Journal Article
SR Electronic
T1 Specialized Histological and Histomorphometrical Analytical Methods for Biocompatibility Testing of Biomaterials for Maxillofacial Surgery in (Pre-) Clinical Studies
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3137
OP 3152
DO 10.21873/invivo.12148
VO 34
IS 6
A1 LINDNER, CAROLIN
A1 PRÖHL, ANNICA
A1 ABELS, MANUEL
A1 LÖFFLER, TOM
A1 BATINIC, MILIJANA
A1 JUNG, OLE
A1 BARBECK, MIKE
YR 2020
UL http://iv.iiarjournals.org/content/34/6/3137.abstract
AB Both preclinical in vivo experiments and clinical trials are indispensable for analysis of tissue reactions in evaluating the compatibility of biomaterials or medical devices, i.e. the cell types interacting with the material, integration or degradation behavior, implant bed vascularization and immunological response. In particular, both the histological workup (including the processes such as embedding, cutting, histochemical and immunohistochemical staining methods), as well as qualitative and quantitative analysis are crucial steps enabling the final evaluation of biocompatibility. We present a short overview of the most important steps of the different workup and analytical methods used in preclinical and clinical biopsies for both novice and experienced researchers in the field of biomaterial science.