RT Journal Article SR Electronic T1 Stereotactic Body Radiotherapy Based on 99mTc-GSA SPECT Image-guided Inverse Planning for Hepatocellular Carcinoma JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 3583 OP 3588 DO 10.21873/invivo.12202 VO 34 IS 6 A1 YUDAI KAI A1 RYO TOYA A1 TETSUO SAITO A1 TOMOHIKO MATSUYAMA A1 YOSHIYUKI FUKUGAWA A1 SHINYA SHIRAISHI A1 YOSHINOBU SHIMOHIGASHI A1 NATSUO OYA YR 2020 UL http://iv.iiarjournals.org/content/34/6/3583.abstract AB Background/Aim: A recent planning study suggested that 99mTc-labelled diethylene triamine pentaacetate-galactosyl human serum albumin (99mTc-GSA) single-photon emission computed tomography (SPECT) image-guided inverse planning (IGIP) shows dosimetric superiority to conventional planning in sparing liver function. Here, we report the first clinical translation of 99mTc-GSA SPECT IGIP for stereotactic body radiotherapy (SBRT) in a patient with hepatocellular carcinoma (HCC). Case Report: A 60-year-old male developed obstructive jaundice caused by recurrent HCC in segment 1 after hepatic resection. He underwent repeated radiotherapy (RT) consisting of 45 Gy in 15 fractions 8 years ago and 30 Gy in 5 fractions 2 years ago. We performed SBRT consisting of 40 Gy in 8 fractions using 99mTc-GSA SPECT-IGIP. We confirmed the dosimetric superiority of functional IGIP to conventional planning. He achieved complete response as assessed using the target volume. The patient has remained alive without recurrence for 18 months. He did not experience radiation-induced liver disease. Conclusion: Recurrent HCC was successfully and safely salvaged via re-irradiation with SBRT using 99mTc-GSA SPECT-IGIP.