RT Journal Article
SR Electronic
T1 A Prospective Evaluation of Tru-Cut Biopsy and Fine-needle Aspiration Cytology in Male Breast Cancer Detection
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3431
OP 3439
DO 10.21873/invivo.12182
VO 34
IS 6
A1 CHIARA ADRIANA PISTOLESE
A1 TOMMASO PERRETTA
A1 GIULIA CLARONI
A1 LUCIA ANEMONA
A1 FRANCESCA SERVADEI
A1 ALBERTO COLLURA
A1 MICHELA CENSI
A1 MARCO MATERAZZO
A1 MARCO PELLICCIARO
A1 FELICIANA LAMACCHIA
A1 GIANLUCA VANNI
YR 2020
UL http://iv.iiarjournals.org/content/34/6/3431.abstract
AB Background: Male breast-cancer (MBC) is often diagnosed late. Our purpose was to evaluate fine-needle aspiration cytology (FNAC) versus Tru-Cut biopsy (TCNB) in MBC diagnosis. Patients and Methods: Men with suspicious breast lesions were prospectively enrolled; 54 met the inclusion criteria and underwent FNAC and TCNB. FNAC, TCNB and gold-standard results were compared. Results: Unsatisfactory results were 11.1% after FNAC and none after TCNB (p=0.027). After gold-standard evaluation, the diagnosis of FNAC and TCNB was confirmed, respectively, in 63.0% and 98.1% and changed in 37.0% and 1.9% (p<0.001). The malignancy rate after FNAC, TCNB and surgery were, respectively, 25.9%, 33.3% and 35.1% (FNAC vs. TCNB p=0.5276, FNAC vs. surgery p=0.404; TCNB vs. surgery p=1). Among invasive carcinomas, 93.8% were identified by FNAC vs. 87.5% by TCNB (p=1); all ductal carcinoma in situ (DCIS) were detected after TCNB and none after FNAC (p=0.1). Conclusion: FNAC leads to a significantly higher number of inadequate samplings and seems to be subject to increased DCIS misdiagnoses. TCNB correlated better to the final histological report.