%0 Journal Article %A CHIARA ADRIANA PISTOLESE %A TOMMASO PERRETTA %A GIULIA CLARONI %A LUCIA ANEMONA %A FRANCESCA SERVADEI %A ALBERTO COLLURA %A MICHELA CENSI %A MARCO MATERAZZO %A MARCO PELLICCIARO %A FELICIANA LAMACCHIA %A GIANLUCA VANNI %T A Prospective Evaluation of Tru-Cut Biopsy and Fine-needle Aspiration Cytology in Male Breast Cancer Detection %D 2020 %R 10.21873/invivo.12182 %J In Vivo %P 3431-3439 %V 34 %N 6 %X Background: Male breast-cancer (MBC) is often diagnosed late. Our purpose was to evaluate fine-needle aspiration cytology (FNAC) versus Tru-Cut biopsy (TCNB) in MBC diagnosis. Patients and Methods: Men with suspicious breast lesions were prospectively enrolled; 54 met the inclusion criteria and underwent FNAC and TCNB. FNAC, TCNB and gold-standard results were compared. Results: Unsatisfactory results were 11.1% after FNAC and none after TCNB (p=0.027). After gold-standard evaluation, the diagnosis of FNAC and TCNB was confirmed, respectively, in 63.0% and 98.1% and changed in 37.0% and 1.9% (p<0.001). The malignancy rate after FNAC, TCNB and surgery were, respectively, 25.9%, 33.3% and 35.1% (FNAC vs. TCNB p=0.5276, FNAC vs. surgery p=0.404; TCNB vs. surgery p=1). Among invasive carcinomas, 93.8% were identified by FNAC vs. 87.5% by TCNB (p=1); all ductal carcinoma in situ (DCIS) were detected after TCNB and none after FNAC (p=0.1). Conclusion: FNAC leads to a significantly higher number of inadequate samplings and seems to be subject to increased DCIS misdiagnoses. TCNB correlated better to the final histological report. %U https://iv.iiarjournals.org/content/invivo/34/6/3431.full.pdf