RT Journal Article
SR Electronic
T1 Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3309
OP 3313
DO 10.21873/invivo.12169
VO 34
IS 6
A1 SHINYA KAMIMURA
A1 AKINORI TAMURA
A1 TOMOTAKA ISHII
A1 TATSUO KANDA
A1 MITSUHIKO MORIYAMA
YR 2020
UL http://iv.iiarjournals.org/content/34/6/3309.abstract
AB Background/Aim: Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach. Materials and Methods: We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project. Results: We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls. Conclusion: Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted.