PT  - JOURNAL ARTICLE
AU  - SHINYA KAMIMURA
AU  - AKINORI TAMURA
AU  - TOMOTAKA ISHII
AU  - TATSUO KANDA
AU  - MITSUHIKO MORIYAMA
TI  - Association of Genetic Polymorphisms With Hepatitis C Virus-related Liver Cirrhosis in Japan
AID  - 10.21873/invivo.12169
DP  - 2020 Nov 01
TA  - In Vivo
PG  - 3309--3313
VI  - 34
IP  - 6
4099  - http://iv.iiarjournals.org/content/34/6/3309.short
4100  - http://iv.iiarjournals.org/content/34/6/3309.full
SO  - In Vivo2020 Nov 01; 34
AB  - Background/Aim: Hepatitis C virus (HCV) infection is an important health problem in the direct-acting antivirals-era. HCV causes life-threatening diseases, such as cirrhosis and hepatocellular carcinoma. Our aim was to examine whether certain single-nucleotide polymorphisms (SNPs) are associated with the prevalence of HCV infections progressing to cirrhosis in the Japanese population by a genome-wide association study-based approach. Materials and Methods: We used DNA extracted from blood specimens of Japanese subjects with the establishment of the BioBank Japan project. Results: We observed statistically significant differences in the frequency of 4 SNPs (rs1989972, rs2293766, rs1877033 and rs4805439) between anti-HCV-positive cirrhotic patients and controls. Conclusion: Four SNPs are associated with susceptibility to cirrhosis among HCV-infected Japanese subjects, while further studies with cohorts other than those sourced from BioBank Japan, must be conducted.