RT Journal Article SR Electronic T1 Clinical Significance of Prognostic Nutritional Index in the Treatment of Esophageal Squamous Cell Carcinoma JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 3451 OP 3457 DO 10.21873/invivo.12184 VO 34 IS 6 A1 KOJI TAKAO A1 HIROTAKA KONISHI A1 HITOSHI FUJIWARA A1 ATSUSHI SHIOZAKI A1 KATSUTOSHI SHODA A1 TOSHIYUKI KOSUGA A1 TAKESHI KUBOTA A1 TOMOHIRO ARITA A1 RYO MORIMURA A1 YASUTOSHI MURAYAMA A1 YOSHIAKI KURIU A1 HISASHI IKOMA A1 MASAYOSHI NAKANISHI A1 KAZUMA OKAMOTO A1 EIGO OTSUJI YR 2020 UL http://iv.iiarjournals.org/content/34/6/3451.abstract AB Background/Aim: The prognostic nutritional index (PNI) is reported to affect postoperative complications and survival of patients with esophageal squamous cell carcinoma (ESCC). The aim of this study is to investigate the clinical significance of PNI in treatment of ESCC. Patients and Methods: Two hundred and sixty-three patients who underwent radical esophagectomy were retrospectively analyzed. PNI was calculated in the pretreatment (pre-Tx), post-neoadjuvant chemotherapy (post-NAC), and postoperative periods. Results: Pre-Tx PNI positively correlated with prognosis irrespective of undergoing NAC (p<0.05). In the patients with NAC, pre-Tx PNI was one of the independent prognostic factors (p=0.04). In patients with low pre-Tx PNI, the prognosis was improved by increase of PNI after NAC (p=0.08), and two cycles of NAC significantly correlated with high post-NAC PNI (p=0.04). Conclusion: Pre-Tx PNI is an independent prognostic factor irrespective of NAC. Patients in whom the post-NAC PNI can be improved have a high probability of obtaining a good prognosis.