PT  - JOURNAL ARTICLE
AU  - KOJI TAKAO
AU  - HIROTAKA KONISHI
AU  - HITOSHI FUJIWARA
AU  - ATSUSHI SHIOZAKI
AU  - KATSUTOSHI SHODA
AU  - TOSHIYUKI KOSUGA
AU  - TAKESHI KUBOTA
AU  - TOMOHIRO ARITA
AU  - RYO MORIMURA
AU  - YASUTOSHI MURAYAMA
AU  - YOSHIAKI KURIU
AU  - HISASHI IKOMA
AU  - MASAYOSHI NAKANISHI
AU  - KAZUMA OKAMOTO
AU  - EIGO OTSUJI
TI  - Clinical Significance of Prognostic Nutritional Index in the Treatment of Esophageal Squamous Cell Carcinoma
AID  - 10.21873/invivo.12184
DP  - 2020 Nov 01
TA  - In Vivo
PG  - 3451--3457
VI  - 34
IP  - 6
4099  - http://iv.iiarjournals.org/content/34/6/3451.short
4100  - http://iv.iiarjournals.org/content/34/6/3451.full
SO  - In Vivo2020 Nov 01; 34
AB  - Background/Aim: The prognostic nutritional index (PNI) is reported to affect postoperative complications and survival of patients with esophageal squamous cell carcinoma (ESCC). The aim of this study is to investigate the clinical significance of PNI in treatment of ESCC. Patients and Methods: Two hundred and sixty-three patients who underwent radical esophagectomy were retrospectively analyzed. PNI was calculated in the pretreatment (pre-Tx), post-neoadjuvant chemotherapy (post-NAC), and postoperative periods. Results: Pre-Tx PNI positively correlated with prognosis irrespective of undergoing NAC (p<0.05). In the patients with NAC, pre-Tx PNI was one of the independent prognostic factors (p=0.04). In patients with low pre-Tx PNI, the prognosis was improved by increase of PNI after NAC (p=0.08), and two cycles of NAC significantly correlated with high post-NAC PNI (p=0.04). Conclusion: Pre-Tx PNI is an independent prognostic factor irrespective of NAC. Patients in whom the post-NAC PNI can be improved have a high probability of obtaining a good prognosis.