TY - JOUR T1 - Clinical Significance of Prognostic Nutritional Index in the Treatment of Esophageal Squamous Cell Carcinoma JF - In Vivo JO - In Vivo SP - 3451 LP - 3457 DO - 10.21873/invivo.12184 VL - 34 IS - 6 AU - KOJI TAKAO AU - HIROTAKA KONISHI AU - HITOSHI FUJIWARA AU - ATSUSHI SHIOZAKI AU - KATSUTOSHI SHODA AU - TOSHIYUKI KOSUGA AU - TAKESHI KUBOTA AU - TOMOHIRO ARITA AU - RYO MORIMURA AU - YASUTOSHI MURAYAMA AU - YOSHIAKI KURIU AU - HISASHI IKOMA AU - MASAYOSHI NAKANISHI AU - KAZUMA OKAMOTO AU - EIGO OTSUJI Y1 - 2020/11/01 UR - http://iv.iiarjournals.org/content/34/6/3451.abstract N2 - Background/Aim: The prognostic nutritional index (PNI) is reported to affect postoperative complications and survival of patients with esophageal squamous cell carcinoma (ESCC). The aim of this study is to investigate the clinical significance of PNI in treatment of ESCC. Patients and Methods: Two hundred and sixty-three patients who underwent radical esophagectomy were retrospectively analyzed. PNI was calculated in the pretreatment (pre-Tx), post-neoadjuvant chemotherapy (post-NAC), and postoperative periods. Results: Pre-Tx PNI positively correlated with prognosis irrespective of undergoing NAC (p<0.05). In the patients with NAC, pre-Tx PNI was one of the independent prognostic factors (p=0.04). In patients with low pre-Tx PNI, the prognosis was improved by increase of PNI after NAC (p=0.08), and two cycles of NAC significantly correlated with high post-NAC PNI (p=0.04). Conclusion: Pre-Tx PNI is an independent prognostic factor irrespective of NAC. Patients in whom the post-NAC PNI can be improved have a high probability of obtaining a good prognosis. ER -