RT Journal Article
SR Electronic
T1 A Role for Angiogenesis in Canine Cutaneous Histiocytoma Regression: Insights into an Old Clinical Enigma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 3279
OP 3284
DO 10.21873/invivo.12165
VO 34
IS 6
A1 COSTA, DIANA
A1 FERREIRA, RITA
A1 PRADA, JUSTINA
A1 QUEIROGA, FELISBINA LUISA
A1 RODRIGUES, PAULA
A1 SILVA, FILIPE
A1 PIRES, ISABEL
YR 2020
UL http://iv.iiarjournals.org/content/34/6/3279.abstract
AB Background/Aim: Canine Cutaneous Histiocytoma (CCH) is a Langerhans' cells benign tumour that undergoes spontaneous regression. The aim of the present study was to investigate the role of angiogenesis, a key step for tumour development, in CCH regression. Materials and Methods: 50 CCH samples were classified into 4 histological groups according to a regression scale, and evaluated for expression of vascular endothelial factor-A (VEGF-A) and its receptor VEGFR-2 as well as microvessel density (MVD). Results: Tumours during early stages of the regressive process had a lower MVD compared to later stages, while CCH tumoural cells showed a limited production of VEGF, but higher levels of VEGFR-2. On the contrary, tumours in advanced phases of regression showed a higher number of neovessels, probably associated with the inflammatory state and the healing process. Conclusion: Our results suggest that angiogenesis may be compromised at early stages of histiocytoma development and this may be a determinant of regression in this tumour.