PT  - JOURNAL ARTICLE
AU  - COSTA, DIANA
AU  - FERREIRA, RITA
AU  - PRADA, JUSTINA
AU  - QUEIROGA, FELISBINA LUISA
AU  - RODRIGUES, PAULA
AU  - SILVA, FILIPE
AU  - PIRES, ISABEL
TI  - A Role for Angiogenesis in Canine Cutaneous Histiocytoma Regression: Insights into an Old Clinical Enigma
AID  - 10.21873/invivo.12165
DP  - 2020 Nov 01
TA  - In Vivo
PG  - 3279--3284
VI  - 34
IP  - 6
4099  - http://iv.iiarjournals.org/content/34/6/3279.short
4100  - http://iv.iiarjournals.org/content/34/6/3279.full
SO  - In Vivo2020 Nov 01; 34
AB  - Background/Aim: Canine Cutaneous Histiocytoma (CCH) is a Langerhans' cells benign tumour that undergoes spontaneous regression. The aim of the present study was to investigate the role of angiogenesis, a key step for tumour development, in CCH regression. Materials and Methods: 50 CCH samples were classified into 4 histological groups according to a regression scale, and evaluated for expression of vascular endothelial factor-A (VEGF-A) and its receptor VEGFR-2 as well as microvessel density (MVD). Results: Tumours during early stages of the regressive process had a lower MVD compared to later stages, while CCH tumoural cells showed a limited production of VEGF, but higher levels of VEGFR-2. On the contrary, tumours in advanced phases of regression showed a higher number of neovessels, probably associated with the inflammatory state and the healing process. Conclusion: Our results suggest that angiogenesis may be compromised at early stages of histiocytoma development and this may be a determinant of regression in this tumour.