@article {ONATSU2577, author = {JUHA ONATSU and RITVA VANNINEN and PEKKA J{\"A}K{\"A}L{\"A} and PIRJO MUSTONEN and KARI PULKKI and MIIKA KORHONEN and MARJA HEDMAN and KINA H{\"O}GLUND and KAJ BLENNOW and HENRIK ZETTERBERG and SANNA-KAISA HERUKKA and MIKKO TAINA}, title = {Tau, S100B and NSE as Blood Biomarkers in Acute Cerebrovascular Events}, volume = {34}, number = {5}, pages = {2577--2586}, year = {2020}, doi = {10.21873/invivo.12075}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: We aimed to analyze the diagnostic value of total tau (T-tau), S-100 calcium-binding protein B (S100B) and neuron-specific enolase (NSE) as blood-based biomarkers in acute ischemic stroke (AIS) or transient ischemic attack (TIA), and their correlation with symptom severity, infarct size, etiology and outcome. Patients and Methods: A total of 102 patients with stroke and 35 with TIA were analyzed. Subacute (63.8{\textpm}50.1 h) plasma T-tau was measured with the single-molecule array (Simoa) method and NSE and S100B were evaluated for comparison. We evaluated biomarkers associations with: (i) diagnosis of AIS or TIA, (ii) cerebral infarction volume in the brain computed tomography, (iii) stroke etiology, (iv) clinical stroke severity and (iv) functional outcome after three months. Results: T-tau was higher in patients with stroke [1.0 pg/ml (IQR=0.3-2.2)] than with TIA [0.5 pg/ml (IQR=0.2-1.0), p=0.02]. The levels of S100B were also increased in stroke [0.082 μg/l (IQR=0.049-0.157)] patients compared to TIA patients [0.045 μg/l (IQR=0.03-0.073), p\<0.001]. However, when the results were adjusted for confounders, significance was lost. Serum levels of NSE among patients with AIS [11.85 μg/l (IQR=9.30-16.14)] compared to those with TIA [10.96 μg/l (IQR=7.98-15.33), p=0.30] were equal. T-tau and S100B concentrations significantly correlated with cerebral infarction volume (r=0.412, p\<0.001) and (r=0.597, p\<0.001), also after corrections (p\<0.001). mRS scores at three-month follow-up correlated with T-tau (r=0.248, p=0.016) and S100B concentrations (r=0.205, p=0.045). Conclusion: For the diagnosis of TIA vs. AIS, blood T-tau and S100B concentrations discriminated only modestly. Additionally, groups were not separable after measuring of T-tau and S100B levels in the blood. T-tau and S100B concentrations correlated with the infarct size, but were not alone predictive for functional outcome at 3 months.}, issn = {0258-851X}, URL = {https://iv.iiarjournals.org/content/34/5/2577}, eprint = {https://iv.iiarjournals.org/content/34/5/2577.full.pdf}, journal = {In Vivo} }