RT Journal Article
SR Electronic
T1 Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2675
OP 2685
DO 10.21873/invivo.12087
VO 34
IS 5
A1 VLADISLAV TRESKA
A1 MARTIN SKALA
A1 KRISTYNA PROCHAZKOVA
A1 ANETA SVEJDOVA
A1 TEREZA PETRAKOVA
A1 JAKUB SEBEK
A1 IVAN RIHA
A1 JACHYM ROSENDORF
A1 ROBERT POLAK
A1 TOMAS SKALICKY
A1 VACLAV LISKA
YR 2020
UL http://iv.iiarjournals.org/content/34/5/2675.abstract
AB Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3- and 5-year OS and RFS were independent of primary tumour location (p<0.59). CLM diameter was negatively associated with OS for the whole cohort (p<0.002), and RCRC (p<0.03) and LCRC (p<0.04) groups, as well as for RFS of those with LCRC (p<0.04). CLM number was negatively associated with RFS for the whole cohort (p<0.0001), RCRC (p<0.02), LCRC (p<0.0001) and RC (p<0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p<0.03), and to worse RFS for the whole cohort (p<0.0003) and for those with LCRC (p<0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p<0.05), LCRC (p<0.05) and RC (p<0.02). Conclusion: Primary tumour location together with clinical risk factors are important for long-term results of surgery CLMs.