PT - JOURNAL ARTICLE AU - VLADISLAV TRESKA AU - MARTIN SKALA AU - KRISTYNA PROCHAZKOVA AU - ANETA SVEJDOVA AU - TEREZA PETRAKOVA AU - JAKUB SEBEK AU - IVAN RIHA AU - JACHYM ROSENDORF AU - ROBERT POLAK AU - TOMAS SKALICKY AU - VACLAV LISKA TI - Long-term Results of Surgery for Colorectal Liver Metastases in Terms of Primary Tumour Location and Clinical Risk Factors AID - 10.21873/invivo.12087 DP - 2020 Sep 01 TA - In Vivo PG - 2675--2685 VI - 34 IP - 5 4099 - http://iv.iiarjournals.org/content/34/5/2675.short 4100 - http://iv.iiarjournals.org/content/34/5/2675.full SO - In Vivo2020 Sep 01; 34 AB - Background/Aim: The aim of the study was to evaluate the influence of primary tumour location and clinical risk factors for long-term results of surgery for colorectal liver metastases (CLMs). Patients and Methods: Overall survival (OS) and recurrence-free survival (RFS) were evaluated in 636 patients. Patients were divided by tumour location (right-/left-sided colorectal cancer: RCRC/LCRC; rectal cancer), and age, gender, number and size of CLMs, type of liver surgery and interval from primary operation were evaluated. Results: One-, 3- and 5-year OS and RFS were independent of primary tumour location (p<0.59). CLM diameter was negatively associated with OS for the whole cohort (p<0.002), and RCRC (p<0.03) and LCRC (p<0.04) groups, as well as for RFS of those with LCRC (p<0.04). CLM number was negatively associated with RFS for the whole cohort (p<0.0001), RCRC (p<0.02), LCRC (p<0.0001) and RC (p<0.02). Radiofrequency ablation and combined procedures led to worse OS for the whole cohort (p<0.03), and to worse RFS for the whole cohort (p<0.0003) and for those with LCRC (p<0.03). A shorter interval between primary colorectal cancer surgery and CLMs procedure was risky for poor OS and RFS of patients with CLMs from RCRC (p<0.05), LCRC (p<0.05) and RC (p<0.02). Conclusion: Primary tumour location together with clinical risk factors are important for long-term results of surgery CLMs.