RT Journal Article SR Electronic T1 Role of Leptin in Neoplastic and Biliary Tree Disease JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2485 OP 2490 DO 10.21873/invivo.12064 VO 34 IS 5 A1 PAOLO IZZO A1 SARA IZZO A1 PIERFRANCESCO DI CELLO A1 GABRIELE D'AMATA A1 MAURIZIO CARDI A1 ANDREA POLISTENA A1 DANIELA MESSINEO A1 LUCIANO IZZO YR 2020 UL http://iv.iiarjournals.org/content/34/5/2485.abstract AB Background/Aim: Leptin is a small hormone of protein nature, it is strongly involved in the regulation of lipid metabolism and its functioning mechanism is not yet well known or whether or not it is actually secreted by cholangiocytes, nor if the biliary tree expresses its receptors. In the past, various studies have tried to correlate leptin levels with certain neoplasms. The aim of this study was to demonstrate that serum leptin values can become a new sensitive and specific serum marker for cholangiocarcinoma. Materials and Methods: Seventy-two patients with gallbladder stones, hepatolithiasis with benign biliary stenosis, cholangiocarcinoma, and a group of patients without hepato-biliary diseases were enrolled in the study. In all cases blood and bile samples were collected for evaluation of leptin levels and liver biopsies were performed to confirm diagnosis. In all patients, both ultrasound and cholangio-magnetic resonance imaging (MRI) were performed to complete the diagnostic procedure. Results: Twenty-two patients were affected by cholangiocarcinoma, 50 by benign biliary disease (35 cholelithiasis and 6 hepatolithiasis and 9 by inflammatory biliary stenosis). The mean values of serum leptin in patients with cholangiocarcinoma were 19.28±8.76 ng/ml, significantly higher than those observed in non-neoplastic biliary diseases. Conclusion: Serum leptin levels might be a useful marker to differentiate patients with cholangiocarcinoma from those with biliary lithiasis and inflammatory stenosis.