RT Journal Article SR Electronic T1 Demethoxycurcumin Inhibits In Vivo Growth of Xenograft Tumors of Human Cervical Cancer Cells JF In Vivo JO In Vivo FD International Institute of Anticancer Research SP 2469 OP 2474 DO 10.21873/invivo.12062 VO 34 IS 5 A1 FU-SHIN CHUEH A1 JIN-CHERNG LIEN A1 YU-CHENG CHOU A1 WEN-WEN HUANG A1 YI-PING HUANG A1 JYE-YU HUANG A1 JUNG-YU KUO A1 WAN-NI HUANG A1 SHOU-YI SHENG A1 HAO-YUN TUNG A1 HUNG-YI CHEN A1 SHU-FEN PENG YR 2020 UL http://iv.iiarjournals.org/content/34/5/2469.abstract AB Background/Aim: Demethoxycurcumin (DMC), a derivate of curcumin from natural plants, exerts antitumor effects on various human cancer cells in vitro and in vivo. Nevertheless, no reports have disclosed whether DMC can affect the growth of human cervical cancer cells in vivo. Therefore we investigated the antitumor effects of DMC on a HeLa cell xenograft model in nude mice in this study. Materials and Methods: Twenty-four nude mice were subcutaneously injected with HeLa cells. All mice were randomly divided into control, low-dose DMC (30 mg/kg), and high-dose DMC (50 mg/kg) groups and individual mice were treated intraperitoneally accordingly every 2 days. Results: DMC significantly reduced tumor weights and volumes of HeLa cell xenografts in mice, indicating the suppression of growth of xenograft tumors. Conclusion: These effects and findings might provide evidence for investigating the potential use of DMC as an anti-cervical cancer drug in the future.