RT Journal Article
SR Electronic
T1 Impact of Acridine Orange in Patients With Local Recurrent Soft Tissue Sarcoma
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2745
OP 2750
DO 10.21873/invivo.12097
VO 34
IS 5
A1 HIROYUKI TSUCHIE
A1 MAKOTO EMORI
A1 NAOHISA MIYAKOSHI
A1 KYOJI OKADA
A1 HIROYUKI NAGASAWA
A1 YASUTAKA MURAHASHI
A1 EMI MIZUSHIMA
A1 JUNYA SHIMIZU
A1 TOSHIHIKO YAMASHITA
A1 YOICHI SHIMADA
YR 2020
UL http://iv.iiarjournals.org/content/34/5/2745.abstract
AB Background/Aim: Local recurrence in soft tissue sarcoma (STS) is a risk factor of worse prognosis. Although a few studies have shown that adjuvant therapy with acridine orange (AO) is effective for local control of primary STS, there have been no reports examining its effectiveness for local recurrence. Patients and Methods: This retrospective study included 36 patients with first local recurrence of STS. Of them, 23 patients received wide excision without AO therapy (Wide group); the other 13 patients received marginal excision with AO therapy (AO group). We compared re-recurrence rates between these two groups. Results: The total re-recurrence rate was 43.5% in the Wide group and 46.2% in the AO group. There was no significant difference in local re-recurrence-free survival and overall survival between the two groups. Conclusion: Adjuvant AO therapy combined with a marginal excision suppresses local re-recurrence rates of individuals with local STS recurrence.