PT  - JOURNAL ARTICLE
AU  - TSUCHIE, HIROYUKI
AU  - EMORI, MAKOTO
AU  - MIYAKOSHI, NAOHISA
AU  - OKADA, KYOJI
AU  - NAGASAWA, HIROYUKI
AU  - MURAHASHI, YASUTAKA
AU  - MIZUSHIMA, EMI
AU  - SHIMIZU, JUNYA
AU  - YAMASHITA, TOSHIHIKO
AU  - SHIMADA, YOICHI
TI  - Impact of Acridine Orange in Patients With Local Recurrent Soft Tissue Sarcoma
AID  - 10.21873/invivo.12097
DP  - 2020 Sep 01
TA  - In Vivo
PG  - 2745--2750
VI  - 34
IP  - 5
4099  - http://iv.iiarjournals.org/content/34/5/2745.short
4100  - http://iv.iiarjournals.org/content/34/5/2745.full
SO  - In Vivo2020 Sep 01; 34
AB  - Background/Aim: Local recurrence in soft tissue sarcoma (STS) is a risk factor of worse prognosis. Although a few studies have shown that adjuvant therapy with acridine orange (AO) is effective for local control of primary STS, there have been no reports examining its effectiveness for local recurrence. Patients and Methods: This retrospective study included 36 patients with first local recurrence of STS. Of them, 23 patients received wide excision without AO therapy (Wide group); the other 13 patients received marginal excision with AO therapy (AO group). We compared re-recurrence rates between these two groups. Results: The total re-recurrence rate was 43.5% in the Wide group and 46.2% in the AO group. There was no significant difference in local re-recurrence-free survival and overall survival between the two groups. Conclusion: Adjuvant AO therapy combined with a marginal excision suppresses local re-recurrence rates of individuals with local STS recurrence.