RT Journal Article
SR Electronic
T1 Combination of 1st and 2nd Week Dosing of Glass Yttrium-90 Microspheres for Superselective Radioembolization
JF In Vivo
JO In Vivo
FD International Institute of Anticancer Research
SP 2763
OP 2768
DO 10.21873/invivo.12100
VO 34
IS 5
A1 HYO-CHEOL KIM
A1 MYUNGSU LEE
A1 JEONG-HOON LEE
A1 JIN CHUL PAENG
A1 YOON JUN KIM
A1 JIN WOOK CHUNG
YR 2020
UL http://iv.iiarjournals.org/content/34/5/2763.abstract
AB Background/Aim: The aim of this study was to address the feasibility of combination of 1st and 2nd week dosing of glass microspheres in the setting of selective radioembolization for large hepatocellular carcinoma (HCC). Patients and Methods: Yttrium-90 radioembolization was performed in 53 patients with single nodular hepatocellular carcinomas larger than 5 cm. A total of 32 patients underwent radioembolization with glass microspheres from a single calibration date (single-dosing group), and 21 patients were treated with a combination of 1st and 2nd week dosing of glass microspheres (combined-dosing group). In the combined-dosing group, the lobar hepatic arteries and subsidiary tumor-feeding arteries were commonly treated with 1st and 2nd week dosing of glass microspheres, respectively. Results: The combined-dosing group tended to have a lower frequency of pain requiring analgesics without statistical significance (p=0.085). The objective response rate at 3 months in single-dosing group and combined-dosing group was 46.9% (15 out of 32) and 66.7% (14 out of 21), respectively. Conclusion: The combined 1st and 2nd week dosing of glass microspheres demonstrated an acceptable toxicity and tumor response when both a lobar hepatic artery and a small tumor-feeding artery need to be treated in one session.