PT  - JOURNAL ARTICLE
AU  - DIRK RADES
AU  - JASPAR WITTELER
AU  - TROELS W. KJAER
AU  - SOEREN TVILSTED
AU  - STEVEN E. SCHILD
TI  - Pre-operative Seizures in Patients With Single Brain Metastasis Treated With Resection Plus Whole-Brain Irradiation and a Boost
AID  - 10.21873/invivo.12091
DP  - 2020 Sep 01
TA  - In Vivo
PG  - 2705--2709
VI  - 34
IP  - 5
4099  - http://iv.iiarjournals.org/content/34/5/2705.short
4100  - http://iv.iiarjournals.org/content/34/5/2705.full
SO  - In Vivo2020 Sep 01; 34
AB  - Background/Aim: Seizures can be the initial symptom of brain metastases. This study investigated pre-treatment seizures in patients with a single lesion. Patients and Methods: Pre-operative seizures were analyzed in 104 patients with a single brain metastasis receiving resection plus whole-brain irradiation and a boost. Prevalence of seizures, risk factors and associations with survival (OS) were evaluated. Results: Thirty patients (34.6%) had seizures prior to neurosurgery. Significant associations between seizures and investigated characteristics were not found. However, age ≤61 years showed a trend (p=0.117) for increased incidence of seizures. Time from diagnosis of malignancy until neurosurgery >12 months was significantly associated with improved OS on univariate analysis (p=0.003). Trends for a positive association with OS were found for no seizures (p=0.054), female gender (p=0.066) and breast cancer (p=0.098). On multivariate analysis, time until neurosurgery >12 months was independently associated (p=0.019) with better OS, and seizures showed a trend (p=0.119) for improved OS. Conclusions: Considering the high prevalence of seizures in this cohort, regular screening and monitoring of these patients appears reasonable. This applies particularly to patients aged ≤61 years.