TY - JOUR T1 - Prognostic Impact of Coagulation Activity in Patients Undergoing Curative Resection for Pancreatic Ductal Adenocarcinoma JF - In Vivo JO - In Vivo SP - 2845 LP - 2850 DO - 10.21873/invivo.12111 VL - 34 IS - 5 AU - KAZUKI MATSUMURA AU - HIROMITSU HAYASHI AU - NORIO UEMURA AU - LIU ZHAO AU - TAKAAKI HIGASHI AU - TAKANOBU YAMAO AU - FUMIMASA KITAMURA AU - YUSUKE NAKAO AU - TOSHIHIKO YUSA AU - RUMI ITOYAMA AU - KATSUNORI IMAI AU - YO-ICHI YAMASHITA AU - HIDEO BABA Y1 - 2020/09/01 UR - http://iv.iiarjournals.org/content/34/5/2845.abstract N2 - Background/Aim: The aim of this study was to elucidate the clinical impact of coagulation disorders on outcomes after curative resection of pancreatic ductal adenocarcinoma. Patients and Methods: Preoperative coagulation activity in 135 patients, who had undergone curative resections for pancreatic ductal adenocarcinoma was retrospectively evaluated and the impact on survival outcomes analyzed. Results: A prolonged prothrombin time-international normalized ratio (PT-INR) (≥1.1) was detected in 23/135 patients (17%). Univariate analysis that showed prolonged PT-INR was associated with worse relapse-free (hazard ratio=1.79, p=0.044) and overall (hazard ratio=2.18, p=0.004) survival. Multivariate analyses showed prolonged PT-INR, large tumor (>30 mm), and lymph node metastasis were independent predictors of poor overall survival. Conclusion: Prolonged PT-INR may be a predictor of poor prognosis in patients with pancreatic ductal adenocarcinoma who have undergone curative resection. Coagulation disorders may be a therapeutic target for improving outcomes of pancreatic ductal adenocarcinoma. ER -