TY - JOUR T1 - Proton Therapy for Primary Renal Cell Carcinoma: The First Nationwide Retrospective Study in Japan JF - In Vivo JO - In Vivo SP - 2883 LP - 2889 DO - 10.21873/invivo.12116 VL - 34 IS - 5 AU - NOBUYOSHI FUKUMITSU AU - HITOSHI ISHIKAWA AU - TAKESHI ARIMURA AU - HITOSHI WADA AU - TOMOAKI OKIMOTO AU - YOSHITAKA SATO AU - HIROMITSU IWATA AU - SHOSEI SHIMIZU AU - HIDEYUKI SAKURAI Y1 - 2020/09/01 UR - http://iv.iiarjournals.org/content/34/5/2883.abstract N2 - Background/Aim: This multi-institutional study aimed to investigate the efficacy and feasibility of proton beam therapy (PBT) for renal cell carcinoma (RCC) in Japan. Patients and Methods: The survival, local control, and toxicities in 22 RCC patients treated between 2001 and 2016 at 6 Japanese PBT institutes were analyzed. Results: The 22 patients comprised 20 men and had a median age of 67 (range=42-88) years. The total irradiation dose was 60-79.6 Gy (relative biological effectiveness). Over a median follow-up of 37 months, the 3-year overall and disease-specific survival rates were 95% and 100%, respectively, and no recurrence occurred. No patient experienced grade 3 or higher adverse events. The serum blood urea nitrogen (p=0.25) and creatinine levels (p=0.95) were not significantly affected, although the mean estimated glomerular filtration rate was reduced by 7.1±11.2 ml/min/1.73 m2. Conclusion: Despite the small number of patients, high-dose PBT can control RCC while maintaining their renal function with high probability, and could be and alternative curative therapy especially for inoperable patients. ER -